Antibody Engineering: Humanized Monoclonal Antibodies (Part 2)

Because CDRs are majorly responsible for recognizing and binding to the target antigen, the scientists thought why not to take the mouse antibody’s CDRs and graft them onto the corresponding variable region of the human antibody. Such generated antibodies are called humanized antibodies.

  • Possess the capability to produce antibodies, a property of plasma cells
  • And they also become immortal, a property of myeloma cells

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